circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1596
DO name: depressive disorder
Disease details: depression
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

Our study illustrates the involvement of the gut microbiota-circHIPK2-astrocyte axis in depression, providing translational evidence that transplantation of the gut microbiota from NLRP3 KO mice may serve as a novel therapeutic strategy for depression.
Other information
Title:

Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2.

Journal: Microbiome
Published: 2019/8/24
PubMed ID: 31439031