circRNA basic information
circBase ID: -
Name: hsa_circ_LRP6
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF2, APC
Associated microRNA: -
Biological function: promote proliferative, migratory and invasive capacities
Molecular mechanism: negatively regulating KLF2 and APC levels
Survival: -
Supported No.:
 2
Description:

circLRP6 was highly expressed in OS and served as an oncogene by binding to LSD1 and EZH2 to inhibit expressions of KLF2 and APC.
Other information
Title:

CircRNA LRP6 promotes the development of osteosarcoma via negatively regulating KLF2 and APC levels.

Journal: Am J Transl Res
Published: 2019/8/10
PubMed ID: 31396323