circRNA basic information
circBase ID: -
Name: hsa_circ_MYBL2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human FLT3-ITD-positive cells (MV4-11, MOLM-13), FLT3-ITD-negative cells 155 (THP-1, HL60, NB4, ML-2,U937, K562), 293t cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FLT3, PTBP1
Associated microRNA: -
Biological function: promotes cell proliferation
Molecular mechanism: activation of FLT3-ITD-dependent signaling pathways
Survival: -
Supported No.:
 1
Description:

circMYBL2 specifically influences FLT3-ITD AML and regulates FLT3 kinase levels through translational regulation.
Other information
Title:

circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression.

Journal: Blood
Published: 2019/8/8
PubMed ID: 31387917