circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH, circ-ITCH
Host Gene: hsa-miR-22
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MG63, U2OS, Saos-2, human osteoblast cell line (hFOB1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN/PI3K/AKT and SP-1 pathways
Associated microRNA: hsa-miR-22
Biological function: promotes proliferation, migration and invasion and represses apoptosis
Molecular mechanism: up-regulating hsa-miR-22
Survival: -
Supported No.:
 2
Description:

Circ-ITCH took effects on apoptosis, viability, proliferation, migration and invasion through restraining PTEN/PI3K/AKT and SP-1 pathways via down-regulating miR-22 in MG63 and Saos-2 cells. Highlights Low expression of circ-ITCH is observed in osteosarcoma tissues and cell lines; Overexpression circ-ITCH suppresses miR-22 expression; Circ-ITCH promotes proliferation and represses apoptosis by up-regulating miR-22; Circ-ITCH promotes migration and invasion by up-regulating miR-22; Circ-ITCH activates PTEN/PI3K/AKT and SP-1 pathways by up-regulating miR-22.
Other information
Title:

The circular RNA circ-ITCH acts as a tumour suppressor in osteosarcoma via regulating miR-22.

Journal: Artif Cells Nanomed Biotechnol
Published: 2019/8/8
PubMed ID: 31387405