circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circ_006100
Host Gene: hsa-miR-195
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: GC cell lines (KN_45, MGC_803, AGS, SGC_7901), human gastric epithelial cell line (GES_1_T)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: GPRC5A
Associated microRNA: hsa-miR-195
Biological function: promote cell growth and metastasis
Molecular mechanism: knockdown of hsa_circ_006100 delayed tumour growth, reduced PCNA expression and upregulated hsa-miR-195 and BCL-2 expression which was restored by hsa-miR-195 inhibition due to GPRC5A/EGFR signalling, and changed the EMT phenotype in vivo
Survival: -
Supported No.:
 1
Description:

Hsa_circ_006100 functions as an oncogene in gastric cancer and exerts its effects via miR-195/GPRC5A signalling.
Other information
Title:

Elevated levels of hsa_circ_006100 in gastric cancer promote cell growth and metastasis via miR-195/GPRC5A signalling.

Journal: Cell Prolif
Published: 2019/7/19
PubMed ID: 31318114