circRNA basic information
circBase ID: -
Name: hsa_circ_BMPR2
Synonym: -
Host Gene: hsa-miR-553
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MCF-7, MDA-MB-231, MDA-MB-468, HEK293T, T47D, SKBR3, ZR-75-1
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
DN
Associated gene: USP4
Associated microRNA: hsa-miR-553
Biological function: inhibit the proliferation and invasion and tamoxifen resistance of breast cancer
Molecular mechanism: function as a hsa-miR-553 sponge and then relieve the suppression of USP4
Survival: -
Supported No.:
 1
Description:

Our findings demonstrated that circBMPR2 might function as a miR-553 sponge and then relieve the suppression of USP4 to inhibit the progression and tamoxifen resistance of breast cancer.
Other information
Title:

Targeting the circBMPR2/miR-553/USP4 Axis as a Potent Therapeutic Approach for Breast Cancer.

Journal: Mol Ther Nucleic Acids
Published: 2019/7/16
PubMed ID: 31302495