circRNA basic information
circBase ID: -
Name: hsa_circ_SMAD7
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ovarian cancer cell lines (A2780, TOV112D, OVCAR-3, SKOV3), normal ovarian cell line (ISOE80)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF6
Associated microRNA: -
Biological function: promoted ovarian cancer cell proliferation and metastasis
Molecular mechanism: suppressing KLF6
Survival: -
Supported No.:
 1
Description:

Our study suggests that circ-SMAD7 promotes the progression of ovarian cancer and enhances cell metastasis and proliferation via suppressing KLF6. In addition, circ-SMAD7 may be a novel therapeutic strategy in ovarian cancer.
Other information
Title:

Circular RNA circ-SMAD7 promoted ovarian cancer cell proliferation and metastasis by suppressing KLF6.

Journal: Eur Rev Med Pharmacol Sci
Published: 2019/7/13
PubMed ID: 31298312