circRNA basic information
circBase ID: -
Name: hsa_circ_DENND4C
Synonym: cDENND4C
Host Gene: hsa-miR-577
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: immortal human brain EC line (hCMEC/D3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-577
Biological function: -
Molecular mechanism: acted as a molecular sponge of hsa-miR-577, which bound to hsa-miR-577 and inhibited its negative regulation of target genes ZO-1, occludin and claudin-1 to regulate BTB permeability
Survival: -
Supported No.:
 1
Description:

the present study indicated that KHDRBS3 could regulate BTB permeability through the cDENND4C/miR-577 axis, which enhanced doxorubicin delivery across BTB.
Other information
Title:

KHDRBS3 regulates the permeability of blood-tumor barrier via cDENND4C/miR-577 axis.

Journal: Cell Death Dis
Published: 2019/7/13
PubMed ID: 31296839