circRNA basic information
circBase ID: -
Name: hsa_circ_NR3C1
Synonym: -
Host Gene: hsa-miR-27a-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human metastatic bladder cancer cell line (T24T), human bladder cancer cell lines (EJ, UMUC3, J82, 5637), human immortalized uroepithelium cell line (SV-HUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: cyclin D1
Associated microRNA: hsa-miR-27a-3p
Biological function: inhibits proliferation
Molecular mechanism: sponging hsa-miR-27a-3p and downregulating cyclin D1 expression
Survival: -
Supported No.:
 2
Description:

our findings further confirm the hypothesis that circRNAs function as microRNA sponges, and our data suggest that circNR3C1 and miR-27a-3p would be potential therapeutic targets for bladder cancer treatment.
Other information
Title:

CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.

Journal: Cancer Lett
Published: 2019/7/1
PubMed ID: 31255724