circRNA basic information
circBase ID: -
Name: hsa_circ_SLC8A1
Synonym: -
Host Gene: hsa-miR-130b, hsa-miR-494
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bladder cancer cell lines (5637, T24, J82, EJ, UMUC, RT4), human urothelial epithelial cell line (SV-HUC-1)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: hsa-miR-130b, hsa-miR-494
Biological function: inhibited cell migration, invasion and proliferation
Molecular mechanism: act as a miRNA sponge to regulate the expression of the hsa-miR-130b/hsa-miR-494 target gene PTEN and downstream signaling pathway
Survival: better
Supported No.:
 1
Description:

CircSLC8A1 acts as a tumor suppressor by a novel circSLC8A1/miR-130b, miR-494/PTEN axis, which may provide a potential biomarker and therapeutic target for the management of bladder cancer.
Other information
Title:

Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN.

Journal: Mol Cancer
Published: 2019/6/24
PubMed ID: 31228937