circRNA basic information
circBase ID: -
Name: hsa_circ_PKD2
Synonym: circ-PKD2
Host Gene: hsa-miR-204-3p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human tongue squamous cell carcinoma cell line (SCC15)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DN
Associated gene: APC2
Associated microRNA: hsa-miR-204-3p
Biological function: inhibited OSCC cell proliferation, migration and invasion, induced apoptosis and cell cycle arrest,
Molecular mechanism: as a sponge for hsa-miR-204-3p and upregulated the expression of adenomatous polyposis coli 2 (APC2), which was the functional target of hsa-miR-204-3p
Survival: -
Supported No.:
 2
Description:

These results demonstrate that the circ-PKD2/miR-204-3p/APC2 axis represents a novel pathway involved in the pathogenesis of OSCC and may serve as a novel therapeutic target of OSCC.
Other information
Title:

circ-PKD2 inhibits carcinogenesis via the miR-204-3p/APC2 axis in oral squamous cell carcinoma.

Journal: Mol Carcinog
Published: 2019/6/18
PubMed ID: 31206208