circRNA basic information
circBase ID: -
Name: hsa_circ_SAMD4A
Synonym: -
Host Gene: hsa-miR-1244
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human osteoblast cell line (hFOB 1.19), OS cell lines (MG-63, U2OS, HOS, 143B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MDM2
Associated microRNA: hsa-miR-1244
Biological function: promoted cell proliferation
Molecular mechanism: circSAMD4A/hsa-miR-1244/MDM2
Survival: -
Supported No.:
 2
Description:

circSAMD4A/miR-1244/MDM2 regulatory loop might be a promising therapeutic target for OS treatment.
Other information
Title:

CircSAMD4A accelerates cell proliferation of osteosarcoma by sponging miR-1244 and regulating MDM2 mRNA expression.

Journal: Biochem Biophys Res Commun
Published: 2019/6/16
PubMed ID: 31200957