circRNA basic information
circBase ID: -
Name: hsa_circ_SERPINE2
Synonym: circ-SERPINE2
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human gastric smooth muscle cells (HGSMC), human GC cells (AZ521, MGC_803)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YWHAZ
Associated microRNA: hsa-miR-375
Biological function: promoted cell proliferation and cell cycle progress and inhibited cell apoptosis
Molecular mechanism: enhancing hsa-miR-375 expression and reducing YWHAZ expression
Survival: -
Supported No.:
 1
Description:

Circ-SERPINE2 is a novel proliferative promoter through the regulation of miR-375/YWHAZ. Circ-SERPINE2/miR-375/YWHAZ axis might provide a novel therapeutic target of GC.
Other information
Title:

Circ-SERPINE2 promotes the development of gastric carcinoma by sponging miR-375 and modulating YWHAZ.

Journal: Cell Prolif
Published: 2019/6/15
PubMed ID: 31199037