circRNA basic information
circBase ID: -
Name: hsa_circ_HIAT1
Synonym: -
Host Gene: hsa-miR-195-5p, hsa-miR-29a-3p, hsa-miR-29c-3p
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OSRC-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: CDC42, AR
Associated microRNA: hsa-miR-195-5p, hsa-miR-29a-3p, hsa-miR-29c-3p
Biological function: suppress proliferation and migration
Molecular mechanism: altering the circHIAT1/hsa-miR-195-5p/29a-3p/29c-3p/CDC42 signals
Survival: -
Supported No.:
 1
Description:

The consequences of AR-suppressed circHIAT1 resulted in deregulating miR-195-5p/29a-3p/29c-3p expression, which increased CDC42 expression to enhance ccRCC cell migration and invasion. Increasing this newly identified signal via circHIAT1 suppressed ARenhanced ccRCC cell migration and invasion. Together, these results suggested that circHIAT1 functioned as a metastatic inhibitor to suppress AR-enhanced ccRCC cell migration and invasion.
Other information
Title:

Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals.

Journal: Cancer Lett
Published: 2017/1/17
PubMed ID: 28089832