circRNA basic information
circBase ID: hsa_circ_0001187
Name: hsa_circ_DOPEY2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: HeLa cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
1
Description:

In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN7 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels.

Other information
Title:

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.

Journal: RNA Biol
Published: 2017/1/13
PubMed ID: 28080204