circRNA basic information
circBase ID: -
Name: mmu_circ_Slc8a1
Synonym: -
Host Gene: mmu-miR-133a
 
 
 
Disease basic information
DO ID:
 114
DO name: heart disease
Disease details: cardiac hypertrophy
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Srf, Ctgf, Adrb1, Adcy6
Associated microRNA: mmu-miR-133a
Biological function: In vivo, AAV9-mediated RNAi knockdown of circSlc8a1 attenuates cardiac hypertrophy from pressure-overload, whereas forced cardiomyocyte specific overexpression of circSlc8a1 resulted in heart failure.
Molecular mechanism: circ_Slc8a1/mmu-miR-133a axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In summary, circSlc8a1 can function as an endogenous sponge for miR-133a in cardiomyocytes. We propose that circSlc8a1 may serve as a novel therapeutic target for cardiac hypertrophy.
Other information
Title:

Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy.

Journal: Cardiovasc Res
Published: 2019/5/23
PubMed ID: 31114845