circRNA basic information
circBase ID: -
Name: -
Synonym: circ-104075
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: cell line
Sample type details: U251
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DS
Associated gene: BCL-9
Associated microRNA: -
Biological function: promotes the Proliferation
Molecular mechanism: Wnt/beta-catenin and PI3K/AKT signaling pathways by matrine were activated by circRNA-104075 overexpression.
Survival: -
Supported No.:
 1
Description:

the present findings suggested that matrine induced apoptosis and autophagy through down-regulating circ-104075 and Bcl-9 expression via inhibition of PI3K/AKT and Wnt-beta-catenin pathways in glioma cells.
Other information
Title:

Matrine induces apoptosis and autophagy of glioma cell line U251 by regulation of circRNA-104075/BCL-9.

Journal: Chem Biol Interact
Published: 2019/5/22
PubMed ID: 31112718