circRNA basic information
circBase ID: -
Name: hsa_circ_HIAT1
Synonym: -
Host Gene: hsa-miR-3171
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (Hep3B, SMMC-7721, HepG2, LM3), human normal liver cell line(L-02)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: hsa-miR-3171
Biological function: inhibits cell growth
Molecular mechanism: circHIAT1/hsa-miR-3171/PTEN pathway
Survival: -
Supported No.:
 1
Description:

Both in vitro and in vivo experiments demonstrated the suppressive effect of circHIAT1 on the HCC cell growth. Mechanistically, circHIAT1 acted as the miR-3171 sponge to upregulate PTEN in HCC.
Other information
Title:

Circular RNA circHIAT1 inhibits cell growth in hepatocellular carcinoma by regulating miR-3171/PTEN axis.

Journal: Biomed Pharmacother
Published: 2019/5/21
PubMed ID: 31108351