circRNA basic information
circBase ID: -
Name: hsa_circ_ORC2
Synonym: circORC2
Host Gene: hsa-miR-19a
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PTEN
Associated microRNA: hsa-miR-19a
Biological function: promote osteosarcoma cell growth and invasion
Molecular mechanism: binds with hsa-miR-19a and enhances its expression, thereby inhibiting downstream PTEN expression and activating Akt pathway
Survival: -
Supported No.:
 1
Description:

circ_ORC2 binds with miR-19a and enhances its expression, thereby inhibiting downstream PTEN expression and activating Akt pathway to promote osteosarcoma cell growth and invasion.
Other information
Title:

Circ_ORC2 enhances the regulatory effect of miR-19a on its target gene PTEN to affect osteosarcoma cell growth.

Journal: Biochem Biophys Res Commun
Published: 2019/5/20
PubMed ID: 31103262