circRNA basic information
circBase ID: hsa_circ_0101432
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: hsa-miR-1258, hsa-miR-622
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal liver cell line (HL-7702), human HCC cell lines (Huh-7, SK-HEP-1, HepG2, HLE)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: MAPK1
Associated microRNA: hsa-miR-1258, hsa-miR-622
Biological function: promoted proliferation and invasion while inhibits apoptosis
Molecular mechanism: inhibiting hsa-miR-1258 and hsa-miR-622 expression and promoting MAPK1 mRNA expression
Survival: -
Supported No.:
 6
Description:

Hsa_circ_0101432 inhibited HCC cell apoptosis, promoted cell proliferation, invasive ability and HCC tumor growth by targeting miR-1258 and miR-622 and upregulating MAPK1 mRNA expression.
Other information
Title:

Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622.

Journal: Cell Cycle
Published: 2019/5/17
PubMed ID: 31095447