circRNA basic information
circBase ID: -
Name: mmu_circ_LRP6
Synonym: -
Host Gene: mmu-miR-205
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: SV40_Mes13
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1 and TLR4/NF-kappaB pathway
Associated microRNA: mmu-miR-205
Biological function: regulates HG-induced proliferation, oxidative stress, ECM accumulation, and inflammation
Molecular mechanism: sponging mmu-miR-205, upregulating HMGB1 and activating TLR4/NF-kappaB pathway
Survival: -
Supported No.:
 1
Description:

these data suggest that circLRP6 regulates HG-induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells via sponging miR-205, upregulating HMGB1 and activating TLR4/NF-kappaB pathway.
Other information
Title:

circLRP6 regulates high glucose-induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells.

Journal: J Cell Physiol
Published: 2019/5/16
PubMed ID: 31087368