circRNA basic information
circBase ID: hsa_circ_0067934
Name: hsa_circ_PRKCI
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GBM cell lines (LN18, U251, LN229, T98G, A172 cells), normal human astrocytes (NHA cells)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PI3K-AKT
Associated microRNA: -
Biological function: facilitate the Proliferation, migration, and EMT and inhibit cell apoptosis
Molecular mechanism: activating PI3K-AKT pathway
Survival: poor
Supported No.:
 1
Description:

Hsa_circ_0067934 is overexpressed and plays an oncogenic role in GBM by promoting cancer cell proliferation and metastasis via upregulation of PI3K-AKT pathway, which suggests that hsa_circ_0067934 is likely to serve as an efficient therapeutic approach in respect of GBM treatment.
Other information
Title:

Up-regulated circular RNA hsa_circ_0067934 contributes to glioblastoma progression through activating PI3K-AKT pathway.

Journal: Eur Rev Med Pharmacol Sci
Published: 2019/5/14
PubMed ID: 31081099