circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_100876
Host Gene: hsa-miR-136
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human osteosarcoma cancer cells lines (143B, Saos_2, MG_63, HOS, os_732, U2_OS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-136
Biological function: promote proliferation
Molecular mechanism: targeting microRNA-136
Survival: poor
Supported No.:
 1
Description:

the dysregulation of circRNA_100876 could induce apoptosis and arrest the cell cycle at G2/M stage, followed by suppression of cell proliferation in osteosarcoma, while silencing miR-136 could restore the cell growth.
Other information
Title:

Dysregulated circRNA_100876 suppresses proliferation of osteosarcoma cancer cells by targeting microRNA-136.

Journal: J Cell Biochem
Published: 2019/5/10
PubMed ID: 31069828