circRNA basic information
circBase ID: hsa_circ_0067934
Name: hsa_circ_PRKCI
Synonym: -
Host Gene: hsa-miR-545, hsa-miR-589
 
 
 
Disease basic information
DO ID:
 231
DO name: motor neuron disease
Disease details: neuronal cell injury
Species: human
Species details: human
Sample type: cell line
Sample type details: SH-SY5Y
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: E2F7
Associated microRNA: hsa-miR-545, hsa-miR-589
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

dysregulation of circPRKCI-miR-545/589-E2F7 axis mediated H(2)O(2)-induced neuronal cell injury. Targeting this novel cascade could be a fine strategy to protect neurons from oxidative stress.
Other information
Title:

CircPRKCI-miR-545/589-E2F7 axis dysregulation mediates hydrogen peroxide-induced neuronal cell injury.

Journal: Biochem Biophys Res Commun
Published: 2019/5/6
PubMed ID: 31053300