circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_000203
Host Gene: mmu-miR-26b-5p
 
 
 
Disease basic information
DO ID:
 114
DO name: heart disease
Disease details: cardiac fibrosis
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: Col1a2, Col3a1, alpha-SMA, CTGF
Associated microRNA: mmu-miR-26b-5p
Biological function: pro-fibrosis effect
Molecular mechanism: derepressing targets of mmu-miR-26b-5p, Col1a2 and CTGF
Survival: -
Supported No.:
 2
Description:

Enforced-expression of circRNA_000203 could increase expressions of Col1a2, Col3a1 and ?±-SMA in mouse cardiac fibroblasts. over-expression of circRNA_000203 could eliminate the anti-fibrosis effect of miR-26b-5p in cardiac fibroblasts.
Other information
Title:

CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts.

Journal: Sci Rep
Published: 2017/1/13
PubMed ID: 28079129