circRNA basic information
circBase ID: -
Name: hsa_circ_Mras
Synonym: cMras
Host Gene: hsa-miR-567
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human non_small cell lung carcinoma (A549, H1975, H1299), normal lung epidermal cell line (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-567
Biological function: inhibiting cell proliferation, migratory
Molecular mechanism: cMras was a sponge of miRNA-567 and released its direct target, PTPRG. cMras overexpression decreased hsa-miR-567 expression and subsequently increased PTPRG expression, while increased miRNA-567 expression blocked the effects induced by cMras. Moreover, PTPRG was downregulated in LUAD and patients with low PTPRG expression exhibited significantly poor prognosis
Survival: better
Supported No.:
 1
Description:

A novel circular RNA cMras and its functions were identified, discovering a cMras/miR-567/PTPRG regulatory pathway in LUAD tumorigenesis and development.
Other information
Title:

Circular RNA cMras inhibits lung adenocarcinoma progression via modulating miR-567/PTPRG regulatory pathway.

Journal: Cell Prolif
Published: 2019/4/24
PubMed ID: 31012177