circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP1
Synonym: -
Host Gene: hsa-miR-653
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal breast epithelial cell (MCF-10A), breast cancer cell lines (T47D, MCF-7, BT549, Hs-578T, MDA-MB-231)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: ZEB2
Associated microRNA: hsa-miR-653
Biological function: facilitate proliferation and inhibit apoptosis
Molecular mechanism: activation of hsa-miR-653 by targeting ZEB2 signaling pathway
Survival: -
Supported No.:
 2
Description:

Hsa_circ_0004771/miR-653/ZEB2 regulatory feedback revealed a new molecular mechanism in the pathogenesis of breast cancer.
Other information
Title:

Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.

Journal: Biosci Rep
Published: 2019/4/14
PubMed ID: 30979827