circRNA basic information
circBase ID: -
Name: hsa_circ_PPP1R12A
Synonym: circPPP1R12A
Host Gene: -
 
 
 
Disease basic information
DO ID:
 219
DO name: colon cancer
Disease details: colon cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CC cell lines (HT-29, HCT-116, SW480, SW620, LoVo, SW48, DLD-1, Caco2, HCT-15), normal human colon mucosal epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promoted the proliferation, migration and invasion abilities
Molecular mechanism: activating Hippo-YAP signaling pathway
Survival: poor
Supported No.:
 1
Description:

In the present study, we illustrated the coding-potential of circRNA circPPP1R12A in the progression of CC. Moreover, we identified that circPPP1R12A-73aa promoted the tumor pathogenesis and metastasis of CC via activating Hippo-YAP signaling pathway.
Other information
Title:

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling.

Journal: Mol Cancer
Published: 2019/3/31
PubMed ID: 30925892