circRNA basic information
circBase ID: -
Name: hsa_circ_SERPINE2
Synonym: -
Host Gene: hsa-miR-1271-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: -
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: ERG
Associated microRNA: hsa-miR-1271-5p
Biological function: alleviate HCs apoptosis and promote anabolism of ECM
Molecular mechanism: CircSERPINE2 acted as a sponge of hsa-miR-1271-5 p and functioned in human chondrocytes (HCs) through targeting hsa-miR-1271-5 p and ERG
Survival: -
Supported No.:
 2
Description:

Our results reveal an important role for a novel circRNA-CircSERPINE2 in OA progression. CircSERPINE2 overexpression could alleviate HCs apoptosis and promote anabolism of ECM through miR-1271-ERG pathway.
Other information
Title:

CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene.

Journal: Ann Rheum Dis
Published: 2019/3/30
PubMed ID: 30923232