circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA-012091
Host Gene: -
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: pulmonary fibrosis in silicosis
Species: human
Species details: human
Sample type: cell line
Sample type details: HPF-a, L929
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes the proliferation and migration
Molecular mechanism: upregulation of downstream PPP1R13B
Survival: -
Supported No.:
 1
Description:

These results suggest that PPP1R13B regulated by circ-012091 promotes the proliferation and migration of lung fibroblasts through ERS and autophagy, and plays a crucial role in the development of pulmonary fibrosis in silicosis.
Other information
Title:

CircRNA-012091/PPP1R13B-mediated Lung Fibrotic Response in Silicosis via Endoplasmic Reticulum Stress and Autophagy.

Journal: Am J Respir Cell Mol Biol
Published: 2019/3/26
PubMed ID: 30908929