circRNA basic information
circBase ID: -
Name: hsa_circ_ERBB2
Synonym: circ-ERBB2
Host Gene: hsa-miR-503, hsa-miR-637
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GC cells (AGS, BGC823, MGC803, SGC7901), normal cell line (GES1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CACUL1, MMP-19
Associated microRNA: hsa-miR-503, hsa-miR-637
Biological function: promoted tumor growth and invasion
Molecular mechanism: target hsa-miR-503/CACUL1 and hsa-miR-637/MMP-19 pathways
Survival: poor
Supported No.:
 2
Description:

The circ-ERBB2 functions as an oncogene in GC and might be useful in developing promising therapies for this fatal malignancy.
Other information
Title:

Upregulation of circular RNA circ-ERBB2 predicts unfavorable prognosis and facilitates the progression of gastric cancer via miR-503/CACUL1 and miR-637/MMP-19 signaling.

Journal: Biochem Biophys Res Commun
Published: 2019/3/12
PubMed ID: 30853181