circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-135a-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human LAC cell lines (H1299, A549, Calu3, SPC-A1), human normal lung epithelial cell (BEAS-2B)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: SIRT1
Associated microRNA: hsa-miR-135a-5p
Biological function: promotes cell growth
Molecular mechanism: regulating hsa-miR-135a-5p/SIRT1 axis and activating Wnt/beta-catenin signaling pathway.
Survival: poor
Supported No.:
 2
Description:

The circ_0001946 might be a potential biomarker for the diagnosis or treatment of LAC.
Other information
Title:

CircRNA has_circ_0001946 promotes cell growth in lung adenocarcinoma by regulating miR-135a-5p/SIRT1 axis and activating Wnt/beta-catenin signaling pathway.

Journal: Biomed Pharmacother
Published: 2019/3/8
PubMed ID: 30841451