circRNA basic information
circBase ID: -
Name: hsa_circ_HMGCS1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 687
DO name: hepatoblastoma
Disease details: hepatoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human HB cell line (HUH6), human normal hepatocyte cell lines (L-O2, HL-7702), human hepatocellular carcinoma cell lines (SMMC-7721, Bel-7404)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF2
Associated microRNA: -
Biological function: promote CRC cell proliferation and inhibit apoptosis
Molecular mechanism: CircHMGCS1 regulates IGF2 and IGF1R expression via sponging hsa-miR-503-5p, and affects the downstream PI3K-Akt signaling pathway
Survival: poor
Supported No.:
 1
Description:

The circHMGCS1/miR-503-5p/IGF-PI3K-Akt axis regulates the proliferation, apoptosis and glutaminolysis of HB cells, implying that circHMGCS1 is a promising therapeutic target and prognostic marker for HB patients.
Other information
Title:

CircHMGCS1 Promotes Hepatoblastoma Cell Proliferation by Regulating the IGF Signaling Pathway and Glutaminolysis.

Journal: Theranostics
Published: 2019/2/28
PubMed ID: 30809316