circRNA basic information
circBase ID: -
Name: hsa_circ_BACH2
Synonym: -
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PTC cell lines (K1, IHH-4, BCPAP, TCP1), human thyroid follicular epithelial cells (Nthy-ori 3-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LMO4
Associated microRNA: hsa-miR-139-5p
Biological function: promote cell proliferation, migration, and invasion
Molecular mechanism: sponging hsa-miR-139-5p and regulating LMO4 expression.
Survival: -
Supported No.:
 1
Description:

The circBACH2 acts as a novel oncogenic RNA that sponges miR-139-5p and can be used as a tumor biomarker of PTC. Whats more, these results revealed that the circBACH2/miR-139-5p/LMO4 axis could be targeted as a potential treatment strategy for PTC.
Other information
Title:

Circular RNA circBACH2 plays a role in papillary thyroid carcinoma by sponging miR-139-5p and regulating LMO4 expression.

Journal: Cell Death Dis
Published: 2019/2/24
PubMed ID: 30796202