circRNA basic information
circBase ID: -
Name: hsa_circ_TADA2As
Synonym: -
Host Gene: hsa-miR-203a-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MCF-10A
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: SOCS3
Associated microRNA: hsa-miR-203a-3p
Biological function: suppressed in vitro cell proliferation, migration, invasion, and clonogenicity and possessed tumor-suppressor capability
Molecular mechanism: circTADA2A-E6 preferentially acted as a hsa-miR-203a-3p sponge to restore the expression of miRNA target gene SOCS3
Survival: -
Supported No.:
 1
Description:

The circTADA2As as promising prognostic biomarkers in TNBC patients, and therapeutic targeting of circTADA2As/miRNA/mRNA network may be a potential strategy for the treatment of breast cancer.
Other information
Title:

circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis.

Journal: Cell Death Dis
Published: 2019/2/23
PubMed ID: 30787278