circRNA basic information
circBase ID: -
Name: hsa_circ_KIF4A
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human mammary epithelial cell line (MCF10A), NTNBC cell lines (MCF-7, T47D, BT474, SKBR3), TNBC cell lines (MDA-MB-453, MDA-MB-468, MDA-MB-231, BT549, HCC38)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promote proliferation
Molecular mechanism: regulated the expression of KIF4A via sponging hsa-miR-375
Survival: poor
Supported No.:
 2
Description:

The circKIF4A-miR-375-KIF4A axis regulates TNBC progression via the competitive endogenous RNA (ceRNA) mechanism. circKIF4A may therefore serve as a prognostic biomarker and therapeutic target for TNBC.
Other information
Title:

circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer.

Journal: Mol Cancer
Published: 2019/2/13
PubMed ID: 30744636