circRNA basic information
circBase ID: hsa_circ_0081143
Name: hsa_circ_COL1A2
Synonym: -
Host Gene: hsa-miR-646
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GC cell lines (SGC7901, MGC803), human gastric epithelial cell line (GES1)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK6
Associated microRNA: hsa-miR-646
Biological function: promotes cisplatin resistance
Molecular mechanism: targeting hsa-miR-646/CDK6 pathway
Survival: -
Supported No.:
 3
Description:

Our study indicated a novel regulatory loop that hsa_circ_0081143/miR-646/CDK6 axis in GC progression. These data suggested that hsa_circ_0081143 might act as a potential novel therapeutic strategy for GC treatment.
Other information
Title:

hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway.

Journal: Cancer Cell Int
Published: 2019/2/9
PubMed ID: 30733646