circRNA basic information
circBase ID: -
Name: hsa_circ_INTS4
Synonym: -
Host Gene: hsa-miR-146b
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal bladder epithelial cell line (SV-HUC-1), BC cell lines (RT4, SW780, J82, 5637, T24, UMUC3, Tccsup)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CARMA3
Associated microRNA: hsa-miR-146b
Biological function: facilitate cell growth, migration and invasion and attenuate cell apoptosis
Molecular mechanism: circINTS4 directly bound to hsa-miR-146b to inhibit its activity of targeting the 3-UTR of CARMA3 mRNA. In addition, circINTS4 could activate the NF-kB signalling pathway and suppress the P38 MAPK signalling pathway in a CARMA3-mediated manner in BC cells.
Survival: -
Supported No.:
 1
Description:

The circINTS4/miR-146b/CARMA3 axis might serve as a promising therapeutic target for BC intervention.
Other information
Title:

The circINTS4/miR-146b/CARMA3 axis promotes tumorigenesis in bladder cancer.

Journal: Cancer Gene Ther
Published: 2019/2/7
PubMed ID: 30723269