circRNA basic information
circBase ID: hsa_circ_0000977
Name: hsa_circ_NOL10
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal bronchial epithelial cells (BEAS_2B), lung cancer cell lines (A549, H1299, H226, H460, H661, SK_MES_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ESRP1, SCML1
Associated microRNA: -
Biological function: inhibiting cell proliferation and cell cycle progression, and promoting the apoptosis
Molecular mechanism: Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family
Survival: -
Supported No.:
 1
Description:

circNOL10 also affects mitochondrial function through regulating the humanin polypeptide family and affecting multiple signaling pathways, ultimately inhibiting cell proliferation and cell cycle progression, and promoting the apoptosis of lung cancer cells, thereby inhibiting lung cancer development.
Other information
Title:

Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family.

Journal: Adv Sci (Weinh)
Published: 2019/1/30
PubMed ID: 30693177