circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: non-cancerous cell lines (Hek293T, BEAS2B, HaCaT, NIH3T3, MEF, MCF-10A), cancer cell lines (MDA-MB-468, MDA-MB-231, 67NR, 66C14, 4T07, 4T1, B16)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: FOXO3, p53
Associated microRNA: -
Biological function: induction of tumor apoptosis
Molecular mechanism: circ-Foxo3 promoted MDM2-induced p53 ubiquitination and subsequent degradation, resulting in an overall decrease of p53
Survival: -
Supported No.:
 3
Description:

silencing endogenous circ-Foxo3 enhanced cell viability, whereas ectopic expression of circ-Foxo3 triggered stress-induced apoptosis and inhibited the growth of tumor xenografts.
Other information
Title:

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity.

Journal: Cell Death Differ
Published: 2016/11/26
PubMed ID: 27886165