circRNA basic information
circBase ID: hsa_circ_0059655
Name: hsa_circ_PYGB
Synonym: -
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 4866
DO name: salivary gland adenoid cystic carcinoma
Disease details: salivary adenoid cystic carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SACC cell line (SACC-83)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: CCND1
Associated microRNA: hsa-miR-338-3p
Biological function: promote migration, proliferation and invasion
Molecular mechanism: competing with hsa-miR-338-3p
Survival: -
Supported No.:
 1
Description:

The ceRNA regulatory network analysis showed that hsa_circ_0059655 and other 14 circRNAs derived from PYGB target on several similar genes by miR-338-3p. Among the 15 circRNAs derived from PYGB, hsa_circ_0059655 has the most relationships in the ceRNA network. Furthermore, after hsa_circ_0059655 was knocked down in SACC-83 cells, the expression of hsa-miR-338-3p was up-regulated while CCND1 was down-regulated. The proliferation, migration, and invasion of SACC-83 cells also decreased after hsa_circ_0059655 knock-downed.
Other information
Title:

Hsa_circRNA_0059655 plays a role in salivary adenoid cystic carcinoma by functioning as a sponge of miR-338-3p.

Journal: Cell Mol Biol (Noisy-le-grand)
Published: 2019/1/24
PubMed ID: 30672444