circRNA basic information
circBase ID: hsa_circ_0058514
Name: hsa_circ_AGFG1
Synonym: -
Host Gene: hsa-miR-195-5p
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human TNBC cell lines (BT-549, MDA-MB-231, SUM-159, MDA-MB-453, MDA-MB-468), normal mammary epithelial cell line (MCF-10A)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: cyclin E1 (CCNE1)
Associated microRNA: hsa-miR-195-5p
Biological function: promote TNBC cell proliferation, mobility and invasion as well as tumorigenesis and metastasis in vivo
Molecular mechanism: circAGFG1/hsa-miR-195-5p/CCNE1
Survival: poor
Supported No.:
 1
Description:

circAGFG1 was evidently up-regulated in TNBC, and its level was correlated with clinical stage, pathological grade and poor prognosis of patients with TNBC. The results indicated that circAGFG1 could promote TNBC cell proliferation, mobility and invasion as well as tumorigenesis and metastasis in vivo. Mechanistic analysis showed that circAGFG1 may act as a ceRNA (competing endogenous RNA) of miR-195-5p to relieve the repressive effect of miR-195-5p on its target cyclin E1 (CCNE1).
Other information
Title:

The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression.

Journal: Mol Cancer
Published: 2019/1/10
PubMed ID: 30621700