circRNA basic information
circBase ID: hsa_circ_0009910
Name: hsa_circ_MFN2
Synonym: -
Host Gene: hsa-miR-20a-5p
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human cell line (1D3), leukemia cell lines (Mono-Mac-6, KG-1, AML2, AML5)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-20a-5p
Biological function: promoted cell growth while inhibits apoptosis
Molecular mechanism: decreasing hsa-miR-20a-5p
Survival: poor
Supported No.:
 3
Description:

Our findings firstly identify that circ_0009910 is significantly upregulated in AML bone marrow samples and might serve as a novel outcome biomarker for AML. Both circ_0009910 and miR-20a-5p may be potential therapeutic targets for future AML treatment.
Other information
Title:

Silencing of circ_0009910 inhibits acute myeloid leukemia cell growth through increasing miR-20a-5p.

Journal: Blood Cells Mol Dis
Published: 2019/1/7
PubMed ID: 30612066