circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-124-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal brain glial cell lines (HEB), human glioma cells (U87, U251, LN229, LN308)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3
Associated microRNA: hsa-miR-124-3p
Biological function: promotes proliferative and invasive capacities
Molecular mechanism: sponging hsa-miR-124-3p to upregulate STAT3 expression
Survival: -
Supported No.:
 7
Description:

In summary, we found that overexpression of circ-HIPK3 promotes proliferative and invasive capacities of glioma cells by sponging miR-124-3p to upregulate STAT3 expression.
Other information
Title:

Circular RNA HIPK3 promotes glioma progression by binding to miR-124-3p.

Journal: Gene
Published: 2018/12/24
PubMed ID: 30576808