circRNA basic information
circBase ID: hsa_circ_0008274
Name: hsa_circ_UGGT2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human thyroid follicular epithelial cell line (Nthy-ori3-1), human thyroid cancer cell lines (TPC-1, 8505C, SW1736)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes cell proliferation and invasion
Molecular mechanism: inhibit the activation of AMPK/mTOR signaling pathway, which was demonstrated by measuring the expression levels of p-AMPK and p-mTOR
Survival: -
Supported No.:
 2
Description:

These results demonstrate that increased hsa_circ_0008274 expression modulates hsa_circ_0008274 to enhance PTC cells proliferation and invasion. Hsa_circ_0008274/ AMPK/mTOR axis may be a novel therapeutic candidate target in PTC treatment.
Other information
Title:

Has_circ_0008274 promotes cell proliferation and invasion involving AMPK/mTOR signaling pathway in papillary thyroid carcinoma.

Journal: Eur Rev Med Pharmacol Sci
Published: 2018/12/24
PubMed ID: 30575918