circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell lines (SW480, SW620, HT29, HCT-116), human normal colon epithelial cell line (FHC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: inhibited CRC cells proliferation and invasion ability
Molecular mechanism: regulating Wnt/beta-catenin signaling pathway
Survival: better
Supported No.:
 1
Description:

We showed that circMTO1 could act as a tumor suppressor affecting the growth and invasion of CRC cells via regulating Wnt/beta-catenin signaling pathway, providing a novel potential biomarker and therapeutic target for CRC treatment.
Other information
Title:

CircMTO1 inhibits cell proliferation and invasion by regulating Wnt/beta-catenin signaling pathway in colorectal cancer.

Journal: Eur Rev Med Pharmacol Sci
Published: 2018/12/18
PubMed ID: 30556859