circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: circPVT1
Host Gene: hsa-miR-125b
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (A549, H292, SPC-A1, H1299, H1650, H1975, SK-MES-1),normal human bronchial epithelial cell line (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: c-Fos, E2F2
Associated microRNA: hsa-miR-125b
Biological function: promoted cell proliferation, invasion while inhibits apoptosis
Molecular mechanism: Sponging hsa-miR-125b and Activating E2F2 Signaling
Survival: -
Supported No.:
 2
Description:

circPVT1 promotes NSCLC cell growth and invasion, and may serve as a promising therapeutic target for NSCLC patients. Therefore, silence of circPVT1 could be a future direction to develop a novel treatment strategy.
Other information
Title:

Circular RNA circPVT1 Promotes Proliferation and Invasion Through Sponging miR-125b and Activating E2F2 Signaling in Non-Small Cell Lung Cancer.

Journal: Cell Physiol Biochem
Published: 2018/12/12
PubMed ID: 30537738