circRNA basic information
circBase ID: hsa_circ_0004015
Name: hsa_circ_CDK14
Synonym: -
Host Gene: hsa-miR-1183
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human lung adenocarcinoma cell lines (A549, H1975, H358, H1299, HCC827), human airway epithelial cell line (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDPK1
Associated microRNA: hsa-miR-1183
Biological function: promote cell viability, proliferation, and invasion
Molecular mechanism: hsa-miR-1183/PDPK1 signaling pathway
Survival: poor
Supported No.:
 2
Description:

oncogenic effects of hsa_circ_0004015 was attributed to the regulation of miR-1183/PDPK1 axis. In conclusion, circ_0016760/miR-1183/PDPK1 signaling pathway might play vital roles in the tumorigenesis of NSCLC.
Other information
Title:

Circular RNA hsa_circ_0004015 regulates the proliferation, invasion, and TKI drug resistance of non-small cell lung cancer by miR-1183/PDPK1 signaling pathway.

Journal: Biochem Biophys Res Commun
Published: 2018/12/5
PubMed ID: 30509491