circRNA basic information
circBase ID:
-
Name:
hsa_circ_ITCH
Synonym:
cir-ITCH, circ-ITCH
Host Gene:
hsa-miR-214, hsa-miR-17
Disease basic information
DO ID:
60081
DO name:
triple-receptor negative breast cancer
Disease details:
triple-negative breast cancer
Species:
human
Species details:
human
Sample type:
tissue, cell line
Sample type details:
MCF-10A, MCF-7, T47D, SK-BR-3, MDA-MB-231, BT-549
circRNA-disease information
Detected method:
Q
Detected method confidence
High
Expression pattern:
DN
Associated gene:
-
Associated microRNA:
hsa-miR-214
,
hsa-miR-17
Biological function:
inhibited TNBC proliferation, invasion and metastasis
Molecular mechanism:
circ-ITCH acts as a sponge for hsa-miR-214 and hsa-miR-17 to increase expression of its ITCH linear isoform, thereby inactivating Wnt/beta-catenin signaling
Survival:
better
Supported No.:
1
Description:
Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/beta-catenin pathway.
Other information
Title:
Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/beta-catenin pathway.
Journal:
Neoplasma
Published:
2018/12/5
PubMed ID:
30509108