circRNA basic information
circBase ID: -
Name: hsa_circ_VRK1
Synonym: -
Host Gene: hsa-miR-624-3p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cells lines (KYSE150, KYSE450, EC109, EC9706), normal human esophageal cell line (Het-1A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN, PI3K
Associated microRNA: hsa-miR-624-3p
Biological function: suppressed ESCC progression
Molecular mechanism: circVRK1 positively regulated PTEN by acting as a molecular sponge of hsa-miR-624-3p. Moreover, circVRK1 decreased the activity of PI3K/AKT signaling pathway by upregulating PTEN
Survival: -
Supported No.:
 1
Description:

The circVRK1 suppressed ESCC progression by regulating miR-624-3p/PTEN axis and PI3K/AKT signaling pathway, suggesting the potential therapeutic value of circVRK1 for ESCC.
Other information
Title:

CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p/PTEN/PI3K/AKT signaling pathway.

Journal: Int J Biol Macromol
Published: 2018/12/7
PubMed ID: 30508543